Endocrine Abstracts

Several studies have addressed the possible role of leptin, the product of the obesity gene (Ob), in ovarian cancer development and progression. Herein, we used the OVCAR-3 cell line expressed both the long (ObRb) and short (ObRt) isoforms of the mRNAs of the leptin receptor, to analyse the effect of leptin on the expression of selected genes involved in the cell cycle and apoptosis. OVCAR-3 cells were exposed to 2 and 20 ng/ml of leptin (noted in non-obese women) or 40 and 10...

Cystic ovarian disease is a common reproductive disorder in women and females of domestic animals, leading to temporal or permanent infertility. Over one in three women with polycystic ovarian syndrome (PCOS) are overweight and have higher serum leptin concentration. Leptin may thereby mediate some of the adverse effect of obesity on ovarian function.In the presented data, we decided to compare the action of two high doses of leptin (20 ng and 40 ng/ml) ...

The aim of the current study was to determine whether the porcine ovary was capable of metabolizing polybrominated diphenyl ether – BDE-47, which is the most abundant congener found in wildlife and in humans. It have been showed by us that this congener disrupt ovarian function by direct action on steroidogenesis. In the current study we analyzed the activity and expression of enzymes involved in phase I (CYP1A1 and CYP2B1/2) and phase II (SULT1A and COMT) of BDE-47 metab...